The AUC values were higher than 0.9 for the K-MMSE and K-MoCA in all education levels except for illiterate patients. K-MMSE and K-MoCA for screening dementia The discriminative values of the K-MMSE and K-MoCA to distinguish dementia from MCI or normal cognition are presented in Table 4. Sex differences also did not affect the prediction of cognitive levels. Age was a confounding factor in the analysis for the MoCA and MCI however, age did not affect the other analyses. Duration of education influenced the predictive value of the MMSE and K-MoCA to diagnose MCI or dementia consistently. Demographic factors influencing the K-MMSE or K-MoCA score The results of the logistic regression analyses are presented in Table 3. The cognitive performances showed a tendency to decline according to the cognitive deterioration on almost all of the subanalyses. Cognitive performances of the subjects Performances on the K-MMSE, K-MoCA, and neuropsychological subtests of groups are presented in Table 2. The patients with normal cognition were significantly more educated than were those with MCI. Compared with non-demented patients, the patients with dementia aged more, suffered longer with PD, and had more severe motor symptoms. The demographic data of the subjects are presented in Table 1. Eleven patients who reported impaired ADL but showed cognitive deficits in only one domain were excluded from this study. According to the diagnostic criteria, the participants were classified into 3 groups: normal cognition ( n = 255), MCI ( n = 161), and dementia ( n = 78). RESULTS Study subjects and demographic data A total of 505 patients were collected from medical records.
Statistical analyses were performed using SPSS Statistics 21 (IBM SPSS Inc., Armonk, NY, USA), and p < 0.05 was considered statistically significant. The point with maximal accuracy was found using the Youden Index. The optimal screening cutoff values of both tests increased with educational level for dementia (K-MMSE 80%, and the optimal diagnostic cutoff value was defined as the highest score that yielded specificity and PPV > 80%, if possible. Results The discriminative powers of the K-MMSE and K-MoCA were excellent for detecting dementia but not for detecting MCI (AUC 0.64–0.85).Predictive values of the K-MMSE and K-MoCA for dementia or MCI were analyzed in groups divided by educational level. Methods We reviewed the medical records of PD patients who had taken the Korean MMSE (K-MMSE), Korean MoCA (K-MoCA), and comprehensive neuropsychological tests.Objective To explore whether the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) can be used to screen for dementia or mild cognitive impairment (MCI) in less educated patients with Parkinson’s disease (PD).